Oxidative stress, glutathione status, sirtuin
and cellular stress response in type 2 diabetes.
Proteins known as sirtuins
are necessary to achieve this life span extension, with sirtuin
1, or SIRT1, often regarded as the most important.
28 ( ANI ): A new study has found that activating a protein called sirtuin
1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice.
A team of scientists at the National Institutes of Health in US conducted experiments on mice models and found that a protein called sirtuin
1 (SIRT1) played a major role in ageing process.
We used sirtinol, a specific and direct inhibitor of the sirtuin
class of deacetylase activity, to inhibit Sirt1 in H1299 cells .
Fischer et al., "A molecular mechanism for direct sirtuin
activation by resveratrol," PLoS ONE, vol.
Our study proves that metformin does indeed have a direct protective action on the vasculature." Experiments on cultivated mouse cells in the laboratory confirmed that metformin has a direct effect on the vascular function through interaction with a protein called sirtuin
1, which is encoded by the SIRT1 gene, known to play a role in ageing.
Detractors had claimed Sinclair's data were influenced by a fluorescent chemical--one that doesn't occur in nature--that he used to measure the activation of sirtuin
proteins by resveratrol-like compounds.
Silent Mating Type Information Regulation 2 Homolog 1 (SIRT1) is the most studied member of the sirtuin
Within this group are Sirtuin
proteins, of which seven isoforms (SIRT1-7) have so far been identified in humans.
on with a glass of wine, knotweed pie or a sirtuin
drug (someday) every night.
They're looking over resveratrol and a series of sirtuin
activators described by the Sirtris group in Nature.