C: Canagliflozin; D: Dapagliflozin; Em: Empagliflozin; Er: Ertugliflozin; HbA1c: Glycosylated hemoglobin; M: Metformin; OD: Once daily; P: Placebo; S: Sitagliptin
KEYWORDS: Type-2 Diabetes, Sitagliptin
, Glimepiride, Glycemic index, Lipid profile, C-reactive protein.
Presented at the Endocrine Society Annual Meeting in New Orleans, Louisiana, with simultaneous publication in the Journal of the American Medical Association, PIONEER 3 was a phase 3a trial investigating the efficacy and long-term safety of oral semaglutide 3 mg, 7 mg and 14 mg compared with sitagliptin
100 mg in adults with type 2 diabetes inadequately controlled with metformin, with or without sulfonylurea, over 78 weeks.
Healthcare company Novo Nordisk Friday announced that its oral semaglutide in 7 mg and 14 mg demonstrated superior A1C and body weight reductions, compared to Januvia (sitagliptin
100 mg), under its PIONEER 3 trial.
Summary: A simple, rapid, and sensitive HPLC-PDA method has been developed for the simultaneous separation and estimation of metformin (MET), sitagliptin
(SIT), glipizide (GPZ), and glibenclamide (GBN).
Other drugs among the year's 10 best sellers that are used regularly by patients with diabetes were atorvastatin (4th overall at $6.3 billion), insulin aspart (7th at $4.8 billion), sitagliptin
(8th at $4.6 billion), insulin isophane (9th at $4.4 billion), and pregabalin (10th at $4.2 billion).
Spending on drugs used by patients with diabetes, 2015 Insulin glargine 1 Rosuvastatin 2 Atorvastatin 4 Insulin aspart 7 Sitagliptin
8 Insulin isophane (NPH) 9 Pregabalin 10 Gabapentin 11 Insulin detemir 12 Metformin 14 Insulin lispro 16 Metformin-sitagliptin 20 The number in each bar represents the drug's place in the top 20 for spending for all drugs.
In our previous studies, we have shown that sitagliptin
can enhance endothelial regeneration after vascular injury.
The search strategy used for PubMed (http://www.ncbi.nlm .nih.gov/pubmed/) and the Cochrane Library (http://www .cochranelibrary.com/) was ("dipeptidyl peptidase-4 inhibitors" OR "dpp-4 inhibitor" OR dutogliptin OR alogliptin OR linagliptin OR saxagliptin OR sitagliptin
OR vildagliptin) AND ("type 1 diabetes" OR t1dm).
Several components of this class, including vildagliptin, sitagliptin
, saxagliptin, alogliptin, and linagliptin, have already been approved for this indication by the US Food and Drug Administration or by the European Medicines Agency; others are awaiting for approval or still in development.
Hence, the present study was planned to evaluate wound healing property of linagliptin, saxagliptin, sitagliptin
, and vildagliptin on excised wounds in non-diabetic Wistar albino rats.