Here is increased availability of cross bridges for generating force of muscle contraction by somatomedins
mediated increase in actin- and myosin-like contractile protein formation.
They added that several factors related to the person's state of nutrition or stress are known to stimulate secretion: starvation, hypoglycemia exercise, excitement and trauma, also it has been found that growth hormone causes the liver and other tissues as muscles to form several small proteins called somatomedins
, many of the somatomedin
effect on growth are similar to the effects of insulin on growth, they are called insulin like growth factor.
GH realizes its peripheral effects indirectly through somatomedins
, predominantly IGF-I (22) which is produced mainly by the liver and to a lesser extent by peripheral tissues (27).
Growth hormone also works indirectly by stimulating liver cells to produce and secrete polypeptide molecules known as somatomedins
, the best studied of which is insulin-like growth factor-1 (IGF-1).