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Related to Sphingolipids: sphingomyelin, Gangliosides


 (sfĭng′gə-lĭp′ĭd, -lī′pĭd)
Any of a group of lipids, such as the ceramides, that yield sphingosine or its derivatives upon hydrolysis. They are major components of cell membranes and play a role in signaling and regulatory functions.

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With more than 20-year-experience, Evonik offers a broad portfolio of more than 10 active ingredients based on sphingolipids which fulfill customer needs and consumer trends.
Sphingony sphingolipids are the naturally occurring, skin-identical molecule called Sphinganine.
The presence of ceramides as a category within sphingolipids was first discovered in the human brain in 1884.
Sphingolipids, a large class of lipids with structural and signaling functions, play important roles in the development of atherosclerosis (Levade et al., 2001).
It did involve, however, an increase in the metabolism of sphingolipids in neuronal cells.
During the last decades, sphingolipids have come to the fore for their involvement in signalling events that control a variety of cellular activities [1].
Ei, A Pharmaceutical SolutionWorks, has signed agreements with European-based professors and technologists for the exclusive worldwide license of a novel class of sphingolipids. Sphingolipids are thought to play a critical role in strengthening the barrier function of the skin, promoting moisture retention and increasing elasticity of the skin.
Sphingolipids have a common hydrophobic tail called ceramide, which is composed of a long chain base and a fatty acid.
Matreya stocks a wide selection of high-purity sphingolipids, phospholipids, fatty acids and esters, and sterols to be used as research standards in biotechnology and pharmaceutical pursuits.
Vitamin K also helps the brain make sphingolipids. These lipids form part of the myelin sheath that coats the nerves as well as neurons' cell membranes.
Investigators at the University of Sao Paulo found that certain substances --such as phospholipids and sphingolipids --were found in differing levels at the time of a first episode of psychosis, allowing them to accurately identify bipolar disorder or schizophrenia or healthy controls 87% of the time.
The few genes of known function encode classical virus-associated functions (such as DNA polymerase, RNA polymerase, Topoisomerase etc) as well as an almost complete pathway for the production of sphingolipids obtained via horizontal gene transfer from the host genome.