73) Histologically, BFH presents as a superficial dermal proliferation of interconnecting strands of basaloid to squamoid
cells that connect to the epidermis and contain small, cystic spaces (Figure 4, A and B).
Papillary processes are lined by multilayered epithelium that contained both squamoid
and transitional epithelium with occasional mucocytes.
Hence, a final diagnosis of urothelial carcinoma, micropapillary variant with adeno and squamoid
differentiation of high-grade, muscle-invasive stage (pT2HGUC) was given.
Areas with Epidermal Cyst Formation (H & E x 100)
Occurrence of atypia may take the form of cellular pleomorphism of the basaloid cells, large polygonal squamoid
cells, with pale vesicular nuclei, increased and abnormal mitotic figures, presence of granular cells and clear cells, and spindle-shaped de-differentiation.
29-31) It is detected in pathologic bladders, denoting squamoid
phenotype change of urothelium.
The variants included squamoid
differentiation which was present in 27 cases (56.
The cystic tumor exhibited thin anastomosing strands of squamoid
and basaloid epithelium with peripheral palisading and small terminal basaloid nubbins (Figure 6).
Centrally, the cells showed squamoid
differentiation with keratin formation, which were more obvious at high power in some areas (Figure-2b).
The tumor cells are poorly differentiated, yielding a polygonal, pleomorphic, spindle, giant, epithelioid, or squamoid
Seventeen cases were of high grade variety consisting predominantly of solid squamoid
areas whereas 26 cases were of the intermediate to low grade variety with mixed solid - cystic to predominantly cystic areas with pools of mucin both within the cystic areas as well as in the stroma.
Tumor cells in sebaceous carcinoma may be large with squamoid
appearance or show basaloid differentiation with limited lipidization.