Stevens-Johnson syndrome

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Related to Stevens-Johnson syndrome: erythema multiforme

Ste·vens-John·son syndrome

A severe inflammatory eruption of the skin and mucous membranes, usually occurring after an infection, with malignancy, or as an allergic reaction to drugs or other substances.

[After Albert Mason Stevens (1884-1945) and Frank Chambliss Johnson (1894-1934), American pediatricians.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Scientists have already found that human leukocyte antigen (HLA) system is responsible for serious and even lethal drug allergies, such as Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN).
The agency also warned that use of injectable whiteners can have toxic effects on the liver, kidneys, and nervous system and may lead to Stevens-Johnson syndrome.
Stevens-Johnson syndrome (SJS) is an acute mucocutaneous process and it is one of the manifestations of severe form of cutaneous eruptions of the skin and mucosal membrane, characterized by severe stomatitis,extensive mucosal necrosis, purulent conjunctivitis and purpuric macules.
The use of sulfasalazine is limited by adverse events including severe skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), life-threatening disorders with high mortality and significant long-term morbidity.
"Although several antiepileptic drugs have been associated with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the class effect and impact of other AEDs are not well described," Eric P.
A team at Moorfields Eye Hospital Dubai (Moorfields) has successfully treated the associated eye conditions for a young patient -- an 11 year-old girl of Pakistani origin -- who presented with Stevens-Johnson syndrome (SJS), a chronic and serious disease that can affect the eyes permanently and severely.
The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two ends of the spectrum of severe immunobullous state, with long-term morbidity and high mortality, characterized by keratinocyte apoptosis.
Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death?
CHICAGO -- Pediatric patients with Stevens-Johnson syndrome and toxic epidermal necrolysis who received purely supportive care and surgical debridement had poorer outcomes, compared with other treatment modalities, a systematic review suggested.
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap are rare but serious diseases.
Dunant et al., "Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs.