The company plans to initially develop MEDI2338 for adult onset Still's disease
, a serious rare and orphan rheumatological disease with no currently approved biologic therapies in the US.
The first approved treatment for adult Still's disease
that has not responded sufficiently to existing therapies.
Another novel presentation involves a heterozygous mutation of the LPIN2 gene manifesting as adult-onset Still's disease
What she has endured in recent years is nothing compared to what she dealt with as an 11-year-old when she spent nearly a year in bed after being diagnosed with Still's disease
, a form of juvenile rheumatoid arthritis that briefly made it too painful for her to walk.<br />"To a sixth-grader, that seemed like the end of the world,'' she said.
Worsening of macrophage activation syndrome in a patient with adult onset Still's disease
after initiation of etanercept therapy.
From childhood Nerys suffered from a debilitating arthritic condition called Still's disease
which meant the use of a wheelchair.
He was initially worked up for pyrexia of unknown origin with differentials of disseminated gonococcal disease, disseminated Tuberculosis (TB), sarcoidosis, Still's disease
, and infective endocarditis.
Adult Still's disease
(AOSD) is an inflammatory disorder of unknown etiology characterized by quotidian (daily) fevers, arthritis, and an evanescent rash and multi-organ involvement .
Eventually, doctors determined that Gordon suffers from adult-onset Still's disease
, an extremely rare form of arthritis that can shut down the body's vital organs and lead to death.
She had been put into a medically induced coma after coming down with an extremely rare illness, adult-onset Still's disease
Different pathologic conditions, including macrophage activation syndrome (MAS), adult onset Still's disease
(AOSD), catastrophic antiphospholipid syndrome (cAPS), and septic shock share a similar clinical presentation characterized by fever, arterial hypotension, and multisystem involvement due to the action of a number of inflammatory mediators .
It is occasionally confused with adult-onset Still's disease
owing to a similar symptomatology and similar "cytokine storm" phenomenon; however, differences in certain lab values and the absence of bone marrow findings distinguish these two conditions .