Subgranular


Also found in: Medical.

Sub`gran´u`lar


a.1.Somewhat granular.
Webster's Revised Unabridged Dictionary, published 1913 by G. & C. Merriam Co.
References in periodicals archive ?
[[beta].sub.3]-AR are highly expressed in the subgranular zone of the dentate gyrus (DG) during development (31).
Results: Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive (+) and DCX+ cells (48.0 [+ or -] 3.1 and 72.0 [+ or -] 3.8 cells/section, respectively) in the subgranular zone (SGZ) of the dentate gyrus (DG) and BrdU+/NeuN+ cells (17.0 [+ or -] 1.5 cells/section) in the granule cell layer as well as in the SGZ.
Using in vivo genetic fate mapping, both quiescent NSCs and transit-amplifying progenitor cells in the subventricular zone and subgranular zone were shown to respond to Shh signaling and contribute to the ongoing neurogenesis in the adult forebrain [131].
A modified stereological approach was used to estimate the total numbers of Ki-67-, PCNA-, and DCX-positive cells present along the entire subgranular zone (SGZ) of the hippocampal DG as previously described [33].
To circumvent this problem, more recent work by Bardella et al (66) used a similar paradigm but with tamoxifen-inducible Nestin-Cre-mediated induction of IDH mutation performed at 5 to 6 weeks of age, targeting Cre to neural progenitor cells within the subventricular zone of the adult animal (as well as the subgranular zone of the dentate gyrus).
G-CSF is also expressed in the neurogenic regions in the adult brain: in the subgranular zone of the dentate gyrus and the subventricular zone [3].
Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.
For each animal, the average BrdU+ cell count was measured by counting five coronal sections of granular and subgranular DG layers using a light microscope with x40 objective lens (Olympus AX70 Provis, Japan), attached to a digital camera (Olympus DP11, Japan).
The actively occurring neurogenesis is restricted to three defined neurogenic regions in the adult brain under normal conditions, namely, (1) the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus [126, 127]; (2) the subventricular zone (SVZ) of the lateral ventricles [129]; and (3) third ventricles of the hypothalamus [130].
The effects of chronic social stress on neurons include reduced neurogenesis in the subgranular zone of the dentate gyrus [3] and reduced expression of glycoprotein M6 in the axonal membrane of glutamatergic neurons [4,5].