sulfasalazine


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sul·fa·sal·a·zine

 (sŭl′fə-săl′ə-zēn′)
n.
A sulfa drug, C18H14N4O5S, used to treat ulcerative colitis.

[sulfa(pyridine), one of its constituents + sal(icylic acid) + az(o)- + -ine.]
Translations

sulfasalazine

n sulfasalazina
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The first group drank distilled water with administration of 0.5% CMC-Na (0.1 ml/l0 g) once a day for 7 d; the other five groups were allowed to drink 5% DSS ad libitum for 7d, and at the same time given 500 mg/kg sulfasalazine, 10 mg/kg HES, 40 mg/kg HES and 80 mg/kg HES 0.5% CMC-Na solution (0.1 ml/10 g), respectively.
"Case reports of fetal malformations linked to sulfasalazine from the inflammatory bowel disease literature didn't pan out in larger studies," said Dr.
Design and Duration: Randomized, double-blind, placebo-controlled trial with a treatment period of six months followed by a six-month observation period during which patients continued on sulfasalazine or mesalamine.
* In our January issue, we stated that only two drugs (corticosteroids and sulfasalazine) are effective against ulcerative colitis.
Contract notice: Conclusion of non-exclusive discount agreements pursuant to section 130a (8) sgb v on medicines containing the active substance sulfasalazine (atc: M01cx02 + a07ec01) as part of a so-called open-house model.
At 24 years of age, the patient experienced swelling of both knees along with difficulty walking and was treated with sulfasalazine and non-steroidal anti-inflammatory drugs (NSAIDs).
Traditional treatment has included nonsteroidal anti-inflammatory drugs--NSAIDs, such as aspirin, ibuprofen (Advil), and naproxen that reduce inflammation and fever--and disease modifying antirheumatic drugs--DMARDs, such as methotrexate, sulfasalazine and leflunomide, to treat persistent inflammation, erosive disease, multiple swollen joints and elevated erythrocyte sedimentation rate (ESR), also known as Sed Rate, and C-reactive Protein (CRP) levels, both of which indicate inflammation.
PHILADELPHIA -- Methotrexate monotherapy, with the addition of either the combination of sulfasalazine plus hydroxychloroquine or etanercept alone at 6 months, if needed, is a reasonable treatment strategy for early rheumatoid arthritis, according to findings presented at the annual meeting of the American College of Rheumatology.
Of the remaining patients, 128 patients were randomized to receive the addition of infliximab to methotrexate, and 130 patients received sulfasalazine, hydroxychloroquine, and methotrexate.
The corrected table is as follows: Table 1 Drugs Used in the Treatment of Rheumatoid Arthritis Nonsteroidal Disease-Modifying Anti- Antiinflammatory Drugs Rheumatic Drugs (Biologic) Anti-TNF Glucocorticoids Etanercept Oral Infliximab Intravenous/Intramuscular Adalimumab Intraarticular Anti-Interleukin-1 Anakinra Disease-Modifying Anti-Rheumatic Anti-CTLA4 Drugs (Traditional) Abatacept Gold salts (Oral, Parenteral) Anti-CD20 Methotrexate Rituximab Hydroxychloroquine Sulfasalazine Leflunomide
A third agent, sulfasalazine (Azulfidine), is metabolized to 5-ASA plus sulfapyridine.
One group took only prednisolone (a corticosteroid) and sulfasalazine. The second group received the same medication, plus allopurinol; the third group received the same as the first, plus DMSO.