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A structure of a helix, especially a DNA molecule, in which the axis of the helix itself is coiled, causing the helix to loop over itself.
intr.v. su·per·coiled, su·per·coil·ing, su·per·coils
To form a supercoil.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˈsuːpəˌkɔɪl) biochem
a coil consisting of coils, a complex coil; particularly, a superhelical structure of DNA
to make into or become a complex coil
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈsu pərˌkɔɪl)

a twist formed by intertwining strands of DNA or by protein chains.
su′per•coiled`, adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
VGXI's proprietary plasmid manufacturing process is recognized for providing the highest purity and supercoil fraction for DNA-based pharmaceuticals, in particular DNA vaccines.
They've conducted heinous acts in the name of science throughout history (like Shark Island, Tuskegee Syphilis Experiment, Nazi Science Experiments, Gosnell's Supercoil Experiment, Puerto Rico Birth Control Experiment, Philadelphia Prison Experiments, Children with Cerebral Palsy at Sonoma State Hospital, University of Iowa 'Monster Study', and so many more).
Among current models, the Carbon Express SuperCoil LT's forearm is adjustable to five positions and has an adjustable butt pad.
Here all the mechanical quantities in the supercoil are described in terms of helix angle and standoff distance s.
In fact, the DNA supercoil is a carefully articulated knot that ties itself up according to rules governing its geometry and electrical forces acting on it from the liquid surroundings.
The Supercoil uses spacers of lead wire encapsulated with Teflon and polyvinylidene chloride tubes to flatten and separate the individual layers of Teflon tubing.
Type II DNA topoisomerases, through DSB induction and repair, act to resolve such obstacles using a repertoire of supercoil introduction/relaxation, catenation/decatenation, and knotting/unknotting processes [197, 198].
For H9c2 cardiomyocytes transfection, the plasmids were acquired in supercoil form using a large scale plasmid extraction kit (EndoFree Plasmid kit, Tiangen, Beijing, China) and confirmed by sequencing.
As the latest model in the Carbon Express Intercept series, the Supercoil ($799; has unlimited potential for customization.
When circular plasmid DNA is subjected to gel electrophoresis, relatively fast migration is observed for the intact supercoil form (form I).
That nature repeatedly creates materials that twist and supercoil -- from tiny proteins and DNA to the yarns, ropes, and cables spun from natural filaments -- suggests that some fundamental process may affect how these diverse structures form.
When circular plasmid DNA is subjected to electrophoresis, relatively fast migration will be observed for the intact supercoil form (Form-I).