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Related to Systemic sclerosis: progressive systemic sclerosis, CREST syndrome


A pathological thickening and hardening of the skin.


(ˌsklɪərəʊˈdɜːmə) ,




(Pathology) a chronic progressive disease most common among women, characterized by a local or diffuse thickening and hardening of the skin
[C19: from New Latin sclerōdermus, from Greek, from sklēros hard + derma skin]


(ˌsklɪər əˈdɜr mə, ˌsklɛr-)

a disease in which connective tissued becomes hardened and rigid.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.scleroderma - an autoimmune disease that affects the blood vessels and connective tissuescleroderma - an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin
autoimmune disease, autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues
morphea - localized scleroderma
2.Scleroderma - genus of poisonous fungi having hard-skinned fruiting bodies: false truffles
fungus genus - includes lichen genera
family Sclerodermataceae, Sclerodermataceae - a family of fungi or order Sclerodermatales with a single-layered peridium; includes earthballs
earthball, hard-skinned puffball, puffball, false truffle - any of various fungi of the genus Scleroderma having hard-skinned subterranean fruiting bodies resembling truffles
Scleroderma aurantium, Scleroderma citrinum - an earthball fungus that is a dingy brownish yellow and a dark purplish interior; the peridium is covered with a pattern of small warts
Scleroderma flavidium, star earthball - an earthball with a smooth upper surface that is at first buried in sand; the top of the fruiting body opens up to form segments like the ray of an umbel
Scleroderma bovista, smooth earthball - an earthball with a peridium that is firm dry and smooth when young but developing cracks when mature; pale orange-yellow when young and reddish brown at maturity


n. escleroderma, esclerodermia, induración y casi total atrofia de la epidermis.


n esclerodermia, esclerosis sistémica progresiva; localized — esclerodermia localizada
References in periodicals archive ?
Survey research was conducted among 64 patients with RA, 60 AS sufferers and 63 patients diagnosed with SSc, including 47 individuals with limited systemic sclerosis (lSSc) and 16 with diffuse systemic sclerosis (dSSc) (Tab 1).
In this month's column, she offers insight into ways to distinguish sclerodermalike fibrosing skin disorders from systemic sclerosis.
Key words: Pulmonary arterial hypertension, connective tissue diseases, systemic sclerosis
The study comprised 44 subjects with systemic sclerosis, 12 of whom were taking a DMARD (mycophenolate mofetil, azathioprine, or hydroxychloroquine), and 49 healthy controls; all underwent pneumococcal vaccination.
Despite its extensive distribution, pansclerotic morphea does not cause the severe organ and vascular fibrosis that is characteristically seen in systemic sclerosis.
The clinical trial, called Scleroderma: Cyclophosphamide or Transplantation (SCOT), compared the safety and potential benefits of the two treatment regimens among 75 people with diffuse systemic sclerosis who had lung or kidney involvement.
Systemic sclerosis (SSc) is an autoimmune disease characterized by antibody production, small vessel vasculopathy, and increased fibroblast deposition of extracellular matrix.
Nonhereditary diseases include vascular anomalies as seen in Raynaud disease, diabetes mellitus, linear scleroderma, systemic sclerosis and psoriasis.
Boehringer Ingelheim reported on Friday the receipt of European Commission (EC) and US Food and Drug Administration (FDA) orphan drug designation for nintedanib for the treatment of systemic sclerosis (SSc, also known as scleroderma), including the associated interstitial lung disease (SSc-ILD).