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 (lī′gās′, -gāz′)
Any of a class of enzymes that catalyze the linkage of two large molecules.

[Latin ligāre, to bind; see leig- in Indo-European roots + -ase.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biochemistry) any of a class of enzymes that catalyse the formation of covalent bonds and are important in the synthesis and repair of biological molecules, such as DNA
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈlaɪ geɪs, -geɪz)

an enzyme that catalyzes the joining of two molecules by forming a covalent bond accompanied by the hydrolysis of ATP. Also called synthetase.
[1961; < Latin lig(āre) to tie, bind]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
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Tissue that is not clearly HCC should be stained with all the available markers including CD34, CK7, glypican 3, HSP-70, and glutamine sythetase to improve diagnostic accuracy (level III).