helper T cell

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helper T cell

n.
Any of a class of T cells that are activated by interacting with antigen-presenting cells, such as a dendritic cells, and then function to activate other cells of the immune system, including B cells, cytotoxic T lymphocytes, and phagocytes. Activated helper T cells usually have CD4 receptors on the surface. Also called T-helper cell.

helper T cell


n.
any of a group of T cells that activate the immune system either by enhancing the production of antibody and other T cells or by mobilizing macrophages to engulf invading particles.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.helper T cell - T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus
T cell, T lymphocyte - a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
References in periodicals archive ?
T helper cell plasticity seems to play a key role in amplitude of diseases.
However, the PHI group did exhibit stronger T helper cell responses, which led the researchers to suggest that "individuals treated in early infection may benefit from [therapeutic] strategies aimed at enhancing virus-specific CTL responses, whereas individuals treated later in infection may benefit from strategies aimed at enhancing HIV-1-specific T helper cell functions as well as broadening CTL responses to combat increased viral diversity." Decreased CTL activity had also been observed in early-disease patients who had been treated from 45 to 90 days after symptomatic acute infection, according to a study published 2 years earlier by researchers from the Aaron Diamond AIDS Research Center (ADARC) in New York and colleagues.
"Our findings, in both animal and human models, indicate that the type of T helper cell present is the determining factor in predicting whether interferon-_ will be effective," Raman added.
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.