Study results indicate that a T-cell response
against a mutant protein can be harnessed to mediate regression of a metastatic epithelial cell cancer.
Our vaccine mobilized a T-cell response
that was able to overtake the SIV invaders in 50 percent of the cases treated.
Previous research had largely focused on the killer T-cell response
after several years of infection.
The goal of current therapeutic vaccines is to generate a cytotoxic T-cell response
, primarily with CD8-positive effector T cells, something that has not been achieved with conventional vaccines that are primarily designed to induce antibodies.
Avoiding sources of false positive T-cell response
, eliminating toxic contaminants that inhibit T-cell activation, and developing and validating reproducible production processes have been the key drivers in the development of this new product line.
Interferon-gamma enzyme-linked immunospot (ELISPOT) analysis indicated that nearly all of the patients mounted a T-cell response
to multiple regions of HPV-16 E6, and 75% did so against HPV-16 E7.
Other researchers are looking at HIV's early impact on the development of the CD4 T-cell response
to the virus itself (the HIV-specific CD4 T-cell response
) as potentially setting the stage for the failure of the immune system to control HIV replication over the long term.
The combination is designed to activate a T-cell response
capable of clearing hepatitis C virus.
Meanwhile, testing led by NADC virologists Julia Ridpath and John Neill indicates that exposing suckling calves to bovine viral diarrhea virus (BVDV) generates a T-cell response
that will fight off the virus.
A large fraction of the virus-specific T-cell response
in mice and humans is directed to conserved determinants of viral core proteins, and many studies in mice have shown that memory T cells can accelerate recovery and reduce illness on virus challenge.
3) They theorized that the initial oncocytic metaplasia in Warthin's tumor induces an early T-cell response
that over time recruits a much larger B-cell population.
In all species we've looked at, including humans, T-cell response
declines with age.