The virus destroys a type of white blood cell in the immune system called a T-helper cell
, and makes copies of itself inside these cells.
Th17 cells have recently been identified as a unique CD4+ T-helper cell
subset, characterized by IL-17 production that promotes tissue inflammation., In this study, similar to Th1 and Th2 cells, circulatory Th17 cell counts also decreased.
Interestingly, our results reveal that despite decreased T-helper cell
response ([IL-2.sup.+] [CD4.sup.+]), the cytotoxic effector activity ([IL-2.sup.+] [CD8.sup.+]) was higher than that observed in healthy volunteers.
It attenuates the T-helper cell
Type 1 response causing suppression of cytokines such as IL-1, IL-6, interferon-[gamma] (INF), and tumor necrosis factor-[alpha] (TNF).
Peripheral T-cell lymphomas of follicular T-helper cell
derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist.
Venkataraman et al., "Peripheral T-cell lymphomas of follicular T-helper cell
derivation with Hodgkin/reed-sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist," American Journal of Surgical Pathology, vol.
For instance, it is well known that naive T-helper cell
(Th0) can differentiate into several specific subsets (Th1, Th2, Th9, Th17, Th22, Treg cells, etc.) under the influence of cytokines .
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell
They discovered that naive, activated, and effector T-killer and T-helper cell
populations occurred in similar percentages in the virus-infected patients and RA patients but not in the healthy controls.
(93) What this means is that too many regulatory T-cells form while T-helper cell
counts drop, resulting in there being more regulatory T-cells than T-helpers.
The reactions included: (1) Reaction with T-lymphocyte (CD-3); (2) reaction with T-helper cell
(CD-4); (3) reaction with T-suppressing cell (CD-8); (4) reaction with B-lymphocyte (CD-20).
Modulation of the lineage-specific differentiation of T-helper cell
subsets represents one of the major contributions of Treg cells to peripheral tolerance .