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CoEnzyme A is essential in numerous cellular processes including the metabolism of fatty acids, amino acids and sugars; the regulation of gene expression; mitochondrial health and the proper functioning of the TCA cycle, which provides the energy cells need to live.
It is generally accepted that energy expenditure will be elevated with increasing exercise volume and intensity, and the TCA cycle will be activated accordingly to oxidize and produce more ATP for the body (Peake et al., 2014), with a concomitant, marked increase in plasma TCA intermediates (Gibala et al., 1988).
Asn supplementation had no effect on mRNA expression of the key enzymes involved in glycolysis, TCA cycle and fatty acid oxidation after 4 h LPS challenge (p>0.1).
The most important pathways in Alzheimer's disease included glycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism, aminoacyl-tRNA biosynthesis, methane metabolism, valine, leucine and isoleucine metabolism, pantothenate and CoA metabolism, TCA cycle, and cysteine and methionine metabolism.
Pyruvate is the only substrate of the TCA cycle. Pyruvate is decarboxylated by pyruvate dehydrogenase (PDH) to acetyl-CoA, which is then condensed with oxalacetate to citrate via the citrate synthase (CS).
As a result, pyruvate generated from glycolysis is unlikely to serve as a primary source of acetyl-CoA needed to enter the TCA cycle. GSA indicated a significant enrichment of genes in the TCA cycle in BR21 (Figure 2, Table S3).
A total of 77 pathways, such as glycolysis/gluconeogenesis, TCA cycle, and pentose phosphate pathway (Table S2), have more than five genes in the human genome.
The ability of cancer cells to undergo aerobic glycolysis allows for the production of glycolytic and TCA cycle intermediates that support biosynthetic pathways required for cell growth and proliferation (11).
In ventricular myocardium, SXSM increased the supply of ATP by enhancing TCA cycle and oxidation-respiratory chain.
In TCA cycle intermediate, citrate was noticed to decrease in Mod group, indicating suppressed TCA cycle.
The results revealed that three metabolic pathways (TCA cycle; alanine, aspartate, and glutamate metabolism; and steroid hormone biosynthesis) of the CFS rats were filtered out before and after exercise, while sphingolipid metabolism alone exhibited significant alterations after exercise only (Figure 4).
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- TCA cycle
- TCA Innovative Product/Technology Award
- TCAC RAWS
- Tcacenco, Pavel