tachyphylaxis

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tach·y·phy·lax·is

 (tăk′ə-fĭ-lăk′sĭs)
n. pl. tach·y·phy·lax·es (-fĭ-lăk′sēz)
1. Rapid desensitization to a toxic substance produced by inoculation with a series of small doses.
2. A rapidly decreasing response to a drug following administration of the initial doses.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

tachyphylaxis

(ˌtækɪfɪˈlæksɪs)
n
(Medicine) very rapid development of tolerance or immunity to the effects of a drug
[New Latin, from tachy- + phylaxis on the model of prophylaxis. See prophylactic]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014