Currently available taxanes
must be delivered intravenously, typically at an infusion center.
inhibit mitosis by decreasing the depolymerization of ss-tubulin.
Intermittent docetaxel treatment offers patients the benefit of a "treatment holiday"--reducing their overall exposure to docetaxel and cumulative toxicity, and potentially delaying resistance to taxanes
APP-111 is a platform technology that may have activity in other tumor types that have previously responded to taxanes
or vinca alkaloids.
Thus, the use of the assay in breast cancer care will result in a more specific use of taxanes
and a reduction of overtreatment thus avoiding serious side effects in patients and saving costs for the health care system.
In addition, PTX administered in the form of taxanes
displayed much shorter MRT than PTX alone, and a possible explanation is that other taxane
components may facilitate the transport of PTX out of the blood.
These include the taxanes
(paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine).
(including paclitaxel and docetaxel) are the most widely used chemotherapy drug class in cancer medicine.
The validity of neuropathy and neuropathic pain measures in patients with cancer receiving taxanes
Although mitosis-inhibiting drugs are used successfully to treat a range of cancers, only about 50 percent of ovarian cancer patients respond to taxanes
and it is not yet possible to identify in advance which patients will benefit.
We shall discuss in this article the continuing saga of individual single gene predictors of sensitivity to anthracyclines and taxanes
, followed by some of the 'multigene' predictors of recurrence risk in EBC.
The data clearly show that this small molecule, oral, targeted agent, in combination with capecitabine, is effective for women whose disease has progressed on previous therapies, including anthracyclines, taxanes
and trastuzumab," said Paolo Paoletti, MD, Senior Vice President of the Oncology Medicine Development Center at GSK.