The first pre-clinical studies in PledPharma's indicative extension of PledOx in neurological damage (CIPN) with taxanes
have been initiated
Proceeds from the planned public offering may be used by the company for development and regulatory activities relating to tesetaxel, an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes
that are widely used in the treatment of cancer, as well as for working capital and general corporate purposes.
It is currently focussed on the development of tesetaxel, an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes
, widely used in the treatment of cancer.
The company added, "Efficacy was observed in patients who had received prior taxanes
and anthracyclines, suggesting a lack of cross-resistance to previous cytotoxic chemotherapy.
Numerous drugs and regimens have been studied in relation to breast cancer, including taxanes
, which are key breast cancer chemotherapy agents, with confirmed antitumor and recurrence-inhibitory effects (1).
All patients received a treatment based on taxanes
Resistance to taxanes
may be intrinsic or acquired due to long term exposure to this chemotherapeutic agent.
Intermittent docetaxel treatment offers patients the benefit of a "treatment holiday"--reducing their overall exposure to docetaxel and cumulative toxicity, and potentially delaying resistance to taxanes
. (7) However, data on the non-inferiority of intermittent vs.
APP-111 is a platform technology that may have activity in other tumor types that have previously responded to taxanes
or vinca alkaloids.
These include the taxanes
(paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine).
(including paclitaxel and docetaxel) are the most widely used chemotherapy drug class in cancer medicine.