terfenadine


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Related to terfenadine: Astemizole
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terfenadine

n terfenadina
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5] The importance of pharmacovigilance can be understood by the fact that it has led to the withdrawal of some of the blockbuster drugs such as rofecoxib, rosiglitazone, and terfenadine.
Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin.
If terfenadine is administered as a mono-therapy, it is metabolized by CYP 3A4 into fexofenadine, which is not a hERG inhibitor.
Some of these medications included: quinidine, amiodarone, sotalol, ketoconazole, itraconazole, miconazole, erythromycin, clarithromycin, and terfenadine, which are known to affect the QT interval or the sympathetic nervous system (n=234).
Potential interactions include antiarrhythmic drugs, antipsychotics, and antihistamines (7) (although the most problematic among these, terfenadine, is no longer marketed).
Several studies found an inhibitory effect of [alpha]-naphthoflavone, ketoconazole, troglitazone, tranylcypromine, ebastine, and terfenadine on the rate of astemizole O-demethylation in human small intestinal microsomes and recombinant CYP2J2 isoform (Matsumoto et al.
Mechanism of the cardiotoxic actions of terfenadine.
An in vivo drug interaction study involving the co-administration under steady-state conditions of paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of paroxetine on terfenadine pharmacokinetics.
Failure of Terfenadine as a antipruritic agent in atopic dogs: Results of double blinded study.
Although terfenadine (30 mg/kg) inhibited plasma extravasation induced by ESGM in the sensitized mice, G.
A meta-analysis of 11 RCTs (1317 patients, average age 32) showed no significant difference in relief of eye symptoms between oral antihistamines (dexchlorpheniramine, terfenadine, and loratadine) and intranasal steroids (budesonide, beclomethasone, fluticasone, and triamcinolone) in patients with seasonal allergies, as measured by various symptom scores?