These low molecular weight compounds include indoles, tetrapyrroles
, arachidonic acid metabolites, and trp metabolites such as FICZ (6-formylindolo[3,2b]-carbazole), ITE (2-(1H-indol-3-ylcarbonyl)-4-thiazol carboxylic acid methyl ester), indirubin, I3C (indole-3carbinol), and BaP (benzo(a)pyrene) [11, 13-15].
The cell biology of tetrapyrroles
: a life and death struggle.
Bischoff et al., "Fusing tetrapyrroles
to graphene edges by surface-assisted covalent coupling," Nature Chemistry, vol.
We have previously demonstrated that bilirubin-related tetrapyrroles
from blue-green alga Spirulina platensis possess strong antiproliferative effects in pancreatic cancer cells through decrease in mitochondrial superoxide levels and consequent shift to reduction in glutathione redox buffer .
Chlorophyll, chlorophyllin and related tetrapyrroles
are significant inducers of mammalian phase 2 cytoprotective genes.
Talalay, "Chlorophyll, chlorophyllin and related tetrapyrroles
are significant inducers of mammalian phase 2 cytoprotective genes," Carcinogenesis, vol.
Then, the accumulated tetrapyrroles
were extracted from the assay mixtures and analyzed by HPLC as described below.
The most commonly tested sensitizers on bacteria have been tricyclic dyes (for example, methylene blue, erythrosine), tetrapyrroles
(for example, porphyrins), and furocoumarins (for example, psoralen).
The chromophoric proteins are those attached with linear tetrapyrroles
and are called phycobiliproteins, while non-chromophoric proteins are called as colorless linker polypeptides.
Also included is an additional chapter on the biosynthesis of major classes of natural products such as eicosanoids, morphine, and tetrapyrroles
, among others.