therapeutic index

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Related to Therapeutic dose: Toxic Dose

therapeutic index

n.
The ratio between the toxic dose and the therapeutic dose of a drug, used as a measure of the relative safety of the drug for a particular treatment.

ther′apeu′tic in′dex



n.
the ratio between the dosage of a drug that causes a lethal effect and the dosage that causes a therapeutic effect.
[1925–30]
References in periodicals archive ?
We are excited to explore the extent of this drug's potential as we progress with dose escalation and approach the expected optimal therapeutic dose of the drug.'
The FDA cleared assay is a non-invasive saliva test that identifies genetic signatures associated with patient metabolization of the drug Coumadin, which will assist doctors in adjusting a patient's therapeutic dose to safer and more effective levels.
The APA Practice Guideline also states that although the highest "usual therapeutic dose" for panic disorder is clonazepam 2 mg/d or alprazolam 4 mg/d, "higher doses are sometimes used for patients who do not respond to the usual therapeutic dose." (1)
There was only a "trace of a nonnarcotic medicine in a therapeutic dose" in his system, reported the New York Times.
Animals (mice or rats) that have received a therapeutic dose of LD50 of a substance will be considered hypnotized if they lose their straightening reflexes when put on their backs.
The risk of misdosing is defined as a clinically significant percentage difference between the initial dose and the therapeutic dose. The therapeutic dose is defined as the dose leading to two consecutive INRs in the therapeutic INR range for at least 14 days apart.
PARIS--Of patients with major depressive disorder who receive a selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI) as their initial pharmacotherapy, 40% do not achieve the minimum therapeutic dose within 4 weeks of diagnosis, according to a real-world study of U.S.
Gradual dose escalation is not required when initiating treatment with Briviact for monotherapy or adjunctive therapy, allowing clinicians to initiate treatment at a therapeutic dose from day one.
This balm offers a therapeutic dose of menthol crystals and peppermint oils, with healing arnica and camphor, according to the company.
A variety of African plants are used for medicinal products, however, the difference between a therapeutic dose and a toxic one is often poorly understood.
Her medications included bumetanide, clonazepam, colchicine .6 mg BID, a therapeutic dose of cyclosporine, flurazepam, gabapentin, levothyroxine, mirtazapine, oxycodone, prednisone, and premarin.
Regarding the effect of a therapeutic dose of pseudoephedrine (PSE) on swimmers' performance:
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