thiamine pyrophosphate

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Noun1.thiamine pyrophosphate - a coenzyme important in respiration in the Krebs cycle
coenzyme - a small molecule (not a protein but sometimes a vitamin) essential for the activity of some enzymes
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Recently we hypothesized that thiamine may be generated by sequential dephosphorylation steps starting from thiamine triphosphate (ThTP) via thiamine diphosphate (ThDP) in the postmortem porcine muscles [30].
[13] Due to decreased utilization of thiamine [lower fraction of thiamine in its active form as thiamine diphosphate, the formation of active thiamine-requiring enzyme such as transketolase, pyruvate dehydrogenase, and [alpha]-ketoglutarate dehydrogenase is inhibited in chronic alcoholics which are the key enzymes in the glucose and amino acid metabolism.