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The fact that the Third Ecumenical Council was held in Ephesus (AD 431) in the first church dedicated to Mary, gave strength to this tradition.
The earliest record of Mary's veneration probably comes from the Third Ecumenical Council at Ephesus in A.
Then came the bitter struggle against Nestorius, Patriarch of Constantinople, over Christ's nature and Mary's Mother of God title; with papal support, a Roman synod, and the Third Ecumenical Council (Ephesus, 431), Cyril prevailed, albeit a patched-up reconciliation (433) did not spare him the need to restate his Christology down to his death on June 27, 444.