Resume therapy the day after the procedure * Ticlopidine (Ticlid
) Withhold 5 d.
It may also interact negatively with certain prescription medications and over-the-counter drugs, including: NSAIDs (such as aspirin and ibuprofen); warfarin (Coumadin); ticlopidine (Ticlid
); clopidogrel (Plavix); and dipyridamole (Persantine) alprazolam (Xanax), haloperidol (Haldol), Trazodone (Desyrel), omeprazole (Prilosec), and nifedipine (Procardia).
* ticlopidine Hcl (Ticlid
): Wait seven days before donating.
Warfarin and three P2Y12 inhibitors--ticagrelor (Brilinta), prasugrel (Effient), and ticlopidine (Ticlid
)-are approved for reducing the risk of thrombotic CV events in patients with ACS.
An hospital include Inderol, absolute contraindication Ticlid
, and Lipitor.
These medicines include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid
), warfarin (Coumadin), and others.
The FDA urges physicians to consider use of other antiplatelet agents in poor metabolizers, such as ticlopidine (Ticlid
) or prasugrel (Effient), or potentially increasing the clopidogrel dose.
Antiplatelet agents such as aspirin, ticlopidine hydrochloride (Ticlid
), dipyridamole (Persantine), and IIb/IIIa receptor antagonists are used to inhibit platelet aggregation for secondary stroke prevention.
Antiplatelet therapy Agent Action LaboratorymMonitoring Aspirin Irreversibly acetylates AspirinWorks cyclooxygenase to PlateletWorks reduce production of VerifyNow thromboxane A2 PFA-100 Chronolog WBA Clopidogrel (Plavix) Binds platelet membrane VerifyNow Ticlopidine (Ticlid
) ADP receptor P2Y12 PFA-100 Eptifibatide Binds GP IIb/IIIa Chronolog WBA (Integrelin) Abciximab (Rheopro) Tirofiban (Aggrastat)
Drug interactions may occur with anticoagulant medications such as warfarin (Coumadin), enoxaparin (Lovenox), heparin, aspirin, and other drugs with aspirin-like effects such as clopidine (Ticlid
) and clopidogrel (Plavix).
An RCT studying secondary prevention of stroke, in which 50% of the study population experienced a TIA as their qualifying event, concluded that ticlopidine (Ticlid
) reduced the risk of stroke by 21% (95% CI, 0.04-0.38; P=.024).
There are three aggregation inhibitors: ciostazol (Pletal), rated C; clopidogrel (Plavix), rated B; and ticlopidine (Ticlid
), rated B.