kallikrein

(redirected from Tissue kallikreins)
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Related to Tissue kallikreins: kallikrein serine protease 1

kallikrein

(ˌkælɪˈkriːɪn; kəˈlɪkriːɪn)
n
(Biochemistry) a type of protease that liberates kinins from kininogens
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
Translations

kal·li·kre·in

n. calicreína, enzima potente de acción vasodilatadora.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
Diamandis, "The emerging roles of human tissue kallikreins in cancer," Nature Reviews Cancer, vol.
The human tissue kallikreins (KLKs) is a family of 15 secreted serine proteases (KLK1-15) with trypsin- or chymotrypsin-like activity and encoded by a cluster of genes tandemly localized on chromosome 19q13.3-4 [28].
Medicinal leeches also secrete hirustasin, which selectively inhibits tissue kallikreins that are largely responsible for the maintenance of a normal level of blood pressure.
Diamandis, "Human tissue kallikreins: physiologic roles and applications in cancer," Molecular Cancer Research, vol.
Human tissue kallikreins: a new enzymatic cascade pathway?
His main research interests are tumor markers, especially a group of enzymes called human tissue kallikreins. His most recent research focuses on proteomic methodologies for identifying novel cancer biomarkers and the physiology of kallikrein enzymes, as they relate to cancer initiation and progression.
Markers that may be useful for analysis of PCa include the prostate-specific tissue kallikreins or other markers of local cancer progression, such as TGF-[[beta].sub.1], interleukin-6 receptor (30), and the urokinase-like plasminogen activation cascade (31, 32).
Among the newly identified prognostic markers for ovarian cancer are the human tissue kallikreins (hKs), a family of 15 trypsin and chymotrypsin-like secreted serine proteases encoded by genes localized in tandem on chromosome 19g13.4 (12).
Human tissue kallikreins (hKs) (6) comprise a subgroup of 15 homologous secreted serine proteases encoded by a tightly clustered multigene family on the long arm of chromosome 19 (KLK1-KLK15)'.
The hormonal regulation of human tissue kallikreins has been studied extensively in several cancer lines in tissue culture, by both reverse transcription-PCR and quantitative immunofluorometric ELISA methods (Table 5) (13,15-17,34-40).
On the basis of knowledge of other prostatic tissue kallikreins (hK2 and hK3), we expected relatively high concentrations of hK4 in prostatic tissue and in prostatic secretions (e.g., seminal plasma).