Williams, "Three new vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin
Ibuprofen, indomethacin, tolmetin
and naproxen are the most commonly used agents.
The most widely used NSAIDs include ibuprofen, indomethacin, tolmetin
and naproxen sodium.
We also noticed that overwhelming majority of NSAIDs were ascribed to phenolcarboxylic acids, such as salicylates (aspirin), propionic acids (flurbiprofen), phenylacetic acids (diclofenac), indoleacetic acids (indometaci), and pyrrolealkanoic acids (tolmetin
) and so on (Dannhardt and Kiefer 2001), which formed the structure basis of inhibitory effects on COX.
The applications of non-classical bioisosterism have also been reported in a number of areas of pharmacology including adrenergic and anti adrenergic drugs [28, 30-31] , several NSAID classes like aryl acetic acid derivatives , cetroplac, tolmetin
, indomethacin, etodolac , antibacterial drugs  , antidepressant of morpholine class  , neuropeptide substance P antagonists (NK1 antagonists) , cholinergic (muscarinic type) agonists , GABA modulators like muscimol, thiomuscimol, isomuscimol as agonists [37-38], peptidomimetics , diuretics like ethacrinic acid  and 5-hyderoxy tryptamine (5-HT1A;1D) agonists like naratryptan and sumatryptan for acute attack of migraine .
Daya, "Non-steroidal antiinflammatory agents, tolmetin
and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons," Metabolic Brain Disease, vol.
Comparative efficacy of topical applied flurbiprofen, diclofenac, tolmetin
, and suprofen for the treatment of experimentally induced blood aqueous barrier disruption in dogs.
The ranking of NSAIDs according to toxicity shows indomethacin, tolmetin
, meclofenamate and Ketoprofen to be the most toxic with coated or buffered aspirin and ibuprofen the least.
Nine traditional NSAIDs (aspirin, etodolac, ibuprofen, indomethacin, ketorolac, meloxicam, naproxen, oxaprozin, and tolmetin
) and one selective COX-2 NSAID (celecoxib) currently have Food and Drug Administration--approved pediatric indications.
Indometazin, piroksikam, tolmetin
ve meklofenamat gibi NSAII'larin kronik kullanimi geriatrik hastalarda cok ciddi yan etki sikligi nedeniyle onerilmez.