The applications of non-classical bioisosterism have also been reported in a number of areas of pharmacology including adrenergic and anti adrenergic drugs [28, 30-31] , several NSAID classes like aryl acetic acid derivatives , cetroplac, tolmetin
, indomethacin, etodolac , antibacterial drugs  , antidepressant of morpholine class  , neuropeptide substance P antagonists (NK1 antagonists) , cholinergic (muscarinic type) agonists , GABA modulators like muscimol, thiomuscimol, isomuscimol as agonists [37-38], peptidomimetics , diuretics like ethacrinic acid  and 5-hyderoxy tryptamine (5-HT1A;1D) agonists like naratryptan and sumatryptan for acute attack of migraine .
The ranking of NSAIDs according to toxicity shows indomethacin, tolmetin
, meclofenamate and Ketoprofen to be the most toxic with coated or buffered aspirin and ibuprofen the least.
5 to 3 mg/kg day / TID to 200 mg Celecoxib ([dagger]) 2 yrs 6 to 12 mg/kg/day / BID to 400 mg Tolmetin
2 yrs 20-30 mg/kg/day / TID Oxaprozin 6 yrs 20-30 mg/kg/day once daily to 1800 mg Etodolac 6 yrs 20 mg/kg once daily to 1200 mg * Available in liquid preparation; ([dagger]) Capsule contents can be sprinkled