Blockbuster products earmarked to come off patent as of last year include Fosamax, Lamictal, Prograf, Risperdal, Topamax
and Valcote/ Depakote.
The consumer products may help offset the loss of revenue when J&J's top-selling migraine pill Topamax
and schizophrenia drug Risperdal lose patent protection next year.
He considers topiramate (Topamax
) a third- or fourth-line drug, prescribing it at 200-300 mg/day.
Carbamazepine (Tegretol), lamotrigine (Lamictal), and topiramate (Topamax
) were the most frequently used background AEDs.
Blockbuster medicines that are expected to face patent expiration in 2009 include Prevacid, Takeda Pharmaceutical Co.'s acid reflux drug, and Topamax
, an epilepsy therapy marketed by Johnson & Johnson.
J&J Wins Order Blocking Mylan Version of Topamax
. Johnson & Johnson (New Brunswick NJ) won a court order blocking Mylan Laboratories Inc.
), whose anti-craving effects have been demonstrated elsewhere, was effective in reducing self-mutilation in a case report.
Two drugs approved for treating epilepsy, topiramate (Topamax
) and zonisamide (Zonegran), have been assessed for an off-label effect on weight loss.
The demands for information pertain to promotion for Risperdal, the seizure medication Topamax
, and the heart-failure treatment Natrecor, the company said.
He added that about 30% of children do not achieve adequate seizure control with existing drugs, which include oxcarbazepine (Trileptal), lamotrigine (Lamictal), gabapentin (Neurontin), and topiramate (Topamax
Freitag is a consultant to Johnson & Johnson, the parent company of Ortho-McNeil Pharmaceutical Inc., which makes topiramate (Topamax
These medications include Risperdal, Fosamax, Topamax
, Lamictal and Depakote