: To premedicate or not to premedicate?
Warkentin et al., "Hypotensive transfusion reactions
can occur with blood products that are leukoreduced before storage," Transfusion, vol.
Tested blood (7048 units) and its components for 2742 patients were surveyed during a period of 6 months and the indications for usage and transfusion reactions
associated with its usage were recorded.
ARDS is the sudden failure of the respiratory system and can result from exposure to diverse direct and indirect insults, including respiratory and non-pulmonary infections, aspiration of gastric contents, trauma and transfusion reactions
, said the company.
Performance Indicators All Institutions Percentiles Performance Indicators N 10th 25th Rate of plasma transfusions that 89 72.5 87.5 met institutional guidelines Rate of pretransfusion 89 90.0 95.0 coagulation testing Rate of posttransfusion 89 75.0 87.0 coagulation testing Plasma transfusion rate 89 81.5 91.8 Rate of reported 89 0.0 0.0 transfusion reactions
All Institutions Percentiles Performance Indicators Median 75th 90th Rate of plasma transfusions that 95.0 100.0 100.0 met institutional guidelines Rate of pretransfusion 97.5 100.0 100.0 coagulation testing Rate of posttransfusion 92.5 95.0 100.0 coagulation testing Plasma transfusion rate 96.8 99.0 100.0 Rate of reported 0.0 2.5 4.0 transfusion reactions
Abbreviation: N, number.
They exclude detailed descriptions of different types of transfusion reactions
in patients and how to deal with them.
DEA 1.1 and 1.2 antibody-antigen interactions result in acute haemolytic transfusion reactions
. DEA 3, 5 and 7 antibody-antigen interaction in vivo results in permanent red blood cell sequestration and loss in 3 to 5 days.
Only adverse transfusion reactions
that led to termination of blood transfusion were defined as transfusion reaction
and were included in the study.
The lungs are affected in the most common of the severe transfusion reactions
, eg transfusion-related acute lung injury and transfusion-associated cardiac overload, as well as the less severe allergic reactions.
Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion reactions
. Blood 2000;95:1138-43.
It is also a risk management, voluntary, confidential system for reporting adverse transfusion reactions
, monitoring the safety, adequacy, reliability and blood wastage; promoting effective guidelines for blood usage and recommending alternatives where appropriate.
These can be formed by the patient as seen in transfusion reactions
or passively acquired as seen in HDN.