aprotinin

(redirected from Trasylol)
Also found in: Medical.

a·pro·ti·nin

 (ā-prōt′n-ĭn, ă-prōt′-)
n.
A polypeptide obtained from bovine lungs that is a protease inhibitor and has been used to reduce bleeding in patients undergoing cardiopulmonary bypass surgery. It was largely withdrawn from the market in 2007 because of safety concerns.

[a- + prot(e)in(ase) + -in.]
References in periodicals archive ?
A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis.
cruzi epimastigotes were harvested from cultures and resuspended in lysis buffer (10 mM Tris-HCl, pH 7.5; 5mM EDTA; 1% Nonidet P-40; 1mM phenylmethanesulfonyl fluoride; 10 mg/mL aprotinin; 50 U/L trasylol; and 10 mg/mL leupeptin) by repeated freezing and thawing cycles.
July 21, 2009) (stating that expert testified that the Hill criteria are generally accepted); In re Trasylol Prods.
For glucagon analysis, blood samples were collected in EDTA vaccutainers treated with aprotinin (Trasylol 10000 KIE/ml; Bayer HealthCare AG 51368) which was added to give a final concentration of 200 KIE per ml of peripheral blood.
Incubation damage in the radioimmunoassay for human plasma glucagon and its prevention with "Trasylol." Am J Med Sci.
The Inhibition of Trasylol of Fibrinolytic Activity Associated with Cardiovascular Operations.
(103.) Drugs that have reached the market with no listed patents, but only regulatory exclusivity, include: Mefloquine HCl (mefloquine hydrochloride), Clozaril (clozapine), Hexalen (altretamine), Leustatin (cladribine), Trasylol (aprotinin bovine), Sclerosol (talc), and Ellence (epirubicin hydrochloride).
Urea antiprotease/antiphosphatase buffer was composed of 7M urea, 2 M thiourea, 5 mmol/L EDTA, 1 mmol/L sodium fluoride, 1 mmol/L sodium orthovanadate, 1 mmol/L sodium pyrophosphate, 2mM PMSF, 1% Triton X-100, and 1 [beta]g/mL aprotinin (Trasylol from Bayer Health Care Pharmaceuticals, Berkley, CA).
For instance, in the Trasylol MDL, centralized in Florida, the defendant was a Pennsylvania corporation with its principal place of business in Indiana.
(2001) evaluaron la inmovilizacion de condrocitos empleando geles de fibrina y alginato de sodio polimerizados con cloruro de calcio y trombina; una vez inmovilizadas las celulas, las cultivaron en frascos Roller usando medio de cultivo DMEM/Ham's F-12 con suero bovino al 10% y Trasylol (aprotinina, Laboratorio Bayer), como resultado obtuvieron el crecimiento celular de condrocitos y el mantenimiento de esta linea celular por el uso de alginato de sodio.
Trasylol was acquired from Bayer (Germany), tissue-type plasminogen activator (tPA) from American Diagnostica (Greenwich, Connecticut, USA) and soya lecithin from Now Natural Foods (Bloomingdale, Illinois, USA).