methotrexate

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meth·o·trex·ate

 (mĕth′ə-trĕk′sāt)
n.
A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.

[methotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)- + -ate.]

methotrexate

(ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-)
n
(Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5

meth•o•trex•ate

(ˌmɛθ oʊˈtrɛk seɪt)

n.
a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction and is used in the treatment of psoriasis and certain cancers.
[1950–55; metho (xy)- + trexate, of unclear derivation]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
Translations

methotrexate

n metotrexato, metotrexate m
References in periodicals archive ?
Under some circumstances, chemotherapeutic drugss like methotrexate (Folex, Trexall, Rheumatrex), mycophenolate mofetil, azathioprine (Asasan, Imuran) and cyclophosphamide (Cytoxan) may be used to control symptoms of lupus.
will market the product under the Trexall trademark and will begin a detailing program directly to physicians starting next month.
Drug Brand Names Acetaminophen * Tylenol Lithium * Eskalith, Lithobid Amitriptyline * Elavil, others Methotrexate * Rheumatrex, Amoxapine * Asendin Trexall Carbamazepine * Tegretol, Milnacipran * Savella Carbatrol, others Nortriptyline * Aventyl, Clomipramine * Anafranil Pamelor Desipramine * Norpramin Olanzapine * Zyprexa Duloxetine * Cymbalta Oxcarbazepine * Trileptal Fluoxetine * Prozac Pregabalin * Lyrica Gabapentin * Neurontin, Topiramate * Topamax, Gralise Topiragen Imipramine * Tofranil Venlafaxine * Effexor Lamotngine * Lamktal Ziprasidone * Geodon