Volanesorsen, developed using Ionis' proprietary antisense technology, is designed to reduce the production of ApoC-III, a protein that is produced in the liver and plays a central role in the regulation of plasma triglycerides
After nearly 15 years, researchers found that women with high triglycerides
suffered fractures more than twice as often as others.
And we know that lowering very high triglycerides
can lower your risk of cardiac events.
After a meal, unneeded calories are stored as triglycerides
and then released by hormones when they are needed for energy.
After researchers adjusted for age and sex, the overall survival rate during 22 years of follow-up was 41% in the low-normal triglycerides
group and 37%, 36%, 35%, and 25% in the higher triglycerides
cohorts, respectively (Pless than .
move into and out of storage via the bloodstream, and are gradually whittled down in size as they circulate.
An estimated 10,000 participants with diabetes and triglycerides
>200mg/dL will be recruited worldwide.
Cholesterol and triglycerides
are fatty substances that travel around in our bloodstream on tiny spheres called lipoproteins.
are generally increased maximally 3-6hrs after a meal particularly in diabetics.
Although statins are effective in reducing heart attack risk, many users still often have high levels of triglycerides
and go on to have heart attacks.
A concentration-dependent association of nonfasting triglycerides
with all-cause mortality was observed.
The study met its primary objective showing CaPre to be safe and effective in reducing triglycerides
in patients with mild to severe hypertriglyceridemia.