Zosano Pharma announced that the previously announced Notice of Allowance of our patent application titled "Method of Rapidly Achieving Therapeutic Concentrations of Triptans
for Treatment of Migraines" has resulted in the issuance of a U.
The last occurred 30 years ago with the development of triptans
7) The evidence that triptans
and serotonin receptor agonists are effective in the treatment of migraine also supports the theory that serotonin neurohormonal signaling pathways play a critical role in the pathogenesis of migraines.
In 2006, the Food and Drug Administration released an alert on serotonin syndrome occurring with combined use of selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) with triptans
are most commonly administered orally, usually as a pill.
Most of the triptans
are categorized as substrates of these enzymes, with the exception of eletriptan, which is categorized as both a substrate and an inducer.
Acute migraine treatment market is dominant by Triptans
and most of them are available as pills.
are available, including two that are approved for use in children; rizitriptan (Maxalt) is approved for children older than age 6 years, and almitriptan (Axert) is approved for those aged 12-17 years.
UKPRwire, Thu Aug 15 2013] In 2012 OTC triptans
increased by 19% in current value terms to reach GBP7 million.
USPRwire, Wed May 15 2013] Towards the end of the review period, all triptans
remained Rx in Kazakhstan.
ClickPress, Wed May 01 2013] In 2012 all drugs classified as triptans
remained Rx in Azerbaijan.
In 155 menstrual migraine attacks treated in double-blind fashion, the two triptans
displayed similar short-term efficacy, as reflected in pain relief and pain-free episodes 2 and 4 hours post treatment.