The introduction of efficient and sensitive hCG assays widened the application of hCG for diagnosis of pregnancy, trophoblastic disease
, and non-trophoblastic neoplasms.
Radioimmunoassay of free betasubunit of human chorionic gonadotropin in diagnosis of high-risk and low-risk gestational trophoblastic disease
1) Other causes of hyperthyroidism in early pregnancy include choriocarcinoma and gestational trophoblastic disease
(partial and complete moles) (TABLE 3).
31) Typically, an AVM is acquired and secondary to trauma related to spontaneous or therapeutic abortion, endometrial carcinoma, or gestational trophoblastic disease
The possibility of persistent trophoblastic disease
and recurrence of tubal ectopic gestation following tubal milking limits its routine use as a conservative procedure.
1,2) The disorder occurs in about 1 in every 1500 pregnancies in the United States, and clinical follow-up is mandatory owing to the risk for persistent gestational trophoblastic disease
following termination of pregnancy.
The aim of this study was to investigate the sensitivity of sonography in evaluation of Gestational Trophoblastic disease
Intact hCG is the predominant form in serum and plasma in pregnancy and trophoblastic disease
, hyperglycosylated hCG in choriocarcinoma and testicular cancer, and the free [beta] subunit in nongestational malignancy.
They cover ovarian cancer, including articles on a model of ovarian serous carcinogenesis, endometrial cancer at the molecular level and as a genetic study, cervical cancer and the impact of HPV and vaccination, gestational trophoblastic disease
, hereditary issues in gynecological cancer, including those involving ovarian and endometrial cancer, and the efficacy of multidisciplinary approach to these cancers.
Goldstein, MD Professor, Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, and Founder and Co-director, New England Trophoblastic Disease
Center, Division of Gynecologic Oncology, Brigham and Women's Hospital, Boston
The most common causes are gestational trophoblastic disease
(hydatidiform mole or choriocarcinoma), hyperstimulation secondary to infertility treatments, and extensive luteinization of theca cells, usually in a multiple gestation.
The diagnostic sensitivity of this tumor marker for detecting trophoblastic disease
is high and approaches that of an ideal tumor marker.