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Related to Trophoblasts: cytotrophoblast, trophoblast layer


The outermost layer of cells of the mammalian blastocyst that attaches the fertilized ovum to the uterine wall and serves as a nutritive pathway for the embryo.

tro′pho·blas′tic adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biology) the outer layer of cells of the embryo of placental mammals, which is attached to the uterus wall and absorbs nourishment from the uterine fluids
[C19: from tropho- + -blast]
ˌtrophoˈblastic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈtrɒf əˌblæst, ˈtroʊ fə-)

the layer of extraembryonic ectoderm that nourishes the embryo or develops into fetal membranes with nutritive functions.
troph`o•blas′tic, adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.trophoblast - the membrane that forms the wall of the blastocyst in early development; aids implantation in the uterine wall; "after implantation of the blastocyst in the uterine wall the trophoblast divides into two layers, the chorion and the placenta"
blastosphere, blastula - early stage of an embryo produced by cleavage of an ovum; a liquid-filled sphere whose wall is composed of a single layer of cells; during this stage (about eight days after fertilization) implantation in the wall of the uterus occurs
tissue layer, membrane - a pliable sheet of tissue that covers or lines or connects the organs or cells of animals or plants
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
In this study, the primary culture of trophoblasts was done by culturing of hatching/hatched blastocysts on feeder cells, which were either mouse embryonic fibroblasts (MEFs) or, for the first time, porcine granulosa cells (PGCs).
Human Placental Trophoblasts: Impacts of Maternal Nutrition
Gestational trophoblastic disease (GTD) is a tumor characterized by proliferation of trophoblasts originating from the placenta.
Spiral artery remodelling begins before cellular interaction with trophoblasts. The first changes in spiral arteries involve endothelial vacuolation, arterial dilation, and smooth muscle disorganization.
In addition, they suggested downregulation of genes in trophoblasts caused by insulin could cause apoptosis and DNA damage to trophoblast cells.
Our results support a role for MEHP as an endocrine disruptor in human trophoblasts by inhibiting hCG secretion.
(13) The proliferating tumor cells recapitulate chorionic villous trophoblasts of various types and are organized in biphasic to triphasic growth patterns: sheets or cords of mononuclear tumor cells (large, intermediate trophoblasts with abundant amphophilic to eosinophilic cytoplasm and/ or smaller cytotrophoblasts) rimmed by layers of multinuclear syncytiotrophoblastic cells (Figure 1).
The basal plate is a mixture of extravillous fetal trophoblasts and all types of maternal cells of the decidualized uterus, including decidual stromal cells, macrophages, and other immune cells.
In the present work, we show that maternal placental tissues from GDM patients and trophoblasts, when exposed to high glucose concentrations, had an upregulation of MMP2 expression.
Adiponectin expression was noted, among others, in the human endometrium as well as uterus, trophoblasts, and conceptuses of mice and pigs [12, 14, 16].
HLA-G, as one of the HLA class I antigens, is expressed in extravillous trophoblasts, and NK cytotoxicity is suppressed by stimulation of KIR by HLA-G [6].