tumor suppressor gene

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Related to Tumor suppressor: p53, tumor suppressor protein

tumor suppressor gene

n.
Any of various genes that normally suppress cellular proliferation and that, when mutated, are associated with the development of certain cancers, including many familial cancers. Also called antioncogene.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tumor suppressor gene - a suppressor gene that blocks unscheduled cell division
suppresser gene, suppressor gene, suppresser, suppressor - a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
References in periodicals archive ?
A BRCA1 gene "silenced" in this manner is unable to do its job as a tumor suppressor.
Objective: Tumor suppressor genes such as TP53, RB1, PTEN and APC are frequently inactivated in sporadic and inherited human tumors.
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Selinexor functions by binding with and inhibiting the nuclear export protein XPO1 (CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function.
SAM and SH3 domain containing protein 1 (SASH1) is identified to be a tumor suppressor gene for breast cancer.
Recessive changes- Those occur in growth-inhibitory pathway genes or commonly in tumor suppressor genes causing loss of function.
Summary: TEHRAN (FNA)- A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division -- the hallmark of the disease -- it also can help make cells more fit by allowing them to fend off stress, findings of a new study said.
In women whose biopsy result did not show cancer, methylation of another tumor suppressor gene, SFRP1, was more common in milk from the biopsied breast than the other one.
Two previously unconnected cancer-promoting proteins team up to ambush a critical tumor suppressor by evicting it from the cell's nucleus and then marking it for death by a protein-shredding mechanism, reports a team led by scientists at the University of Texas M.
The findings suggest the potential for a specific, single microRNA (miR-34a) to be used as a drug candidate in cancer therapy to increase programmed cell-death (apoptosis) in the context of the potent tumor suppressor p53.
3-q31 and supported a possible tumor suppressor model.
The patent protects Introgen's non-viral delivery platform for delivering one or more of almost 40 tumor suppressor genes for inducing apoptosis, or programmed cell death, in cancer cells.