tumor suppressor gene

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Related to Tumor suppressor proteins: TP53

tumor suppressor gene

n.
Any of various genes that normally suppress cellular proliferation and that, when mutated, are associated with the development of certain cancers, including many familial cancers. Also called antioncogene.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.tumor suppressor gene - a suppressor gene that blocks unscheduled cell division
suppresser gene, suppressor gene, suppresser, suppressor - a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
References in periodicals archive ?
E6 and E7 are considered oncogenes because they cause loss of function of the critical tumor suppressor proteins p53 and the retinoblastoma protein.
Selinexor functions by binding with and inhibiting the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function.
Many studies in cancer biology have focused on the importance of tumor suppressor proteins and how they may protect cells from progressing to cancer.
In high risk types, the E6 and E7 proteins inactivate the tumor suppressor proteins, p53 and Rb, respectively.