tumor suppressor gene

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tumor suppressor gene

n.
Any of various genes that normally suppress cellular proliferation and that, when mutated, are associated with the development of certain cancers, including many familial cancers. Also called antioncogene.
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Noun1.tumor suppressor gene - a suppressor gene that blocks unscheduled cell division
suppresser gene, suppressor gene, suppresser, suppressor - a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
References in periodicals archive ?
This work suggests a strong genetic component to melanoma, including several susceptibility genes and loss of a tumor supressor gene (which can occur through heredity or damage by sunlight).
Genzyme Genetics will assume the rights to existing licenses for diagnostic use of p53, a tumor supressor gene that is mutated in over half of all cancers, and the MSH2 and APC genes, which in mutated form can increase the risk of certain types of colon cancer.
discovered the APC gene in 1991; APC is a tumor supressor gene and normally prevents the formation of tumors in the colon.

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