uricosuric agents


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Related to uricosuric agents: allopurinol, xanthine oxidase inhibitors

uricosuric agents

Used to reduce the uric acid in the body, and thus to treat gout.
References in periodicals archive ?
The commonly used urate-lowering agents in clinical practice include two classes: urate production inhibitors and uricosuric agents.
In addition, hyperuricemia was also noted and controlled by uricosuric agents postoperatively.
in a study on Chinese diabetic patients found that hyperuricemia was significantly associated with abnormal albuminuria in patients without diuretics or use of uricosuric agents or alcohol.
Several options for lowering sUA are available, including xanthine oxidase inhibitors (allopurinol, febuxostat) that prevent the production of uric acid, uricosuric agents (probenecid), and one biologic agent (pegloticase) that enzymatically degrades uric acid to allantoin.
Treatment options may include uricosuric agents that enhance uric acid excretion, xanthine oxidase inhibitors that decrease urate formation and uricase enzymes that catalyze the conversion to allantoin, a more soluble purine product.
12) URAT1 blockade is now appreciated to be the mechanism of several currently-prescribed uricosuric agents, including probenecid.
Uricosuric agents, such a probenecid, and the xanthine oxidase inhibitor allopurinol are used for this purpose.
Uricosuric agents, such a probenecid, and the xanthine oxidase inhibitor allopurinol are used for reducing urate levels, but uricosuric agents increase the risk of uric acid crystallization in the urine and associated stone formation.
Fortunately, novel, effective antihyperuricemics are in clinical development to counter the limitations of allopurinol and uricosuric agents.