The two main classes of BPH drugs: alpha blockers like Flomax and UroXatral
, which relax the muscles of the bladder neck and prostate, and 5-alpha reductase inhibitors like Proscar and Avodart, which lower levels of hormones produced by the prostate.
This product is the generic version of Uroxatral
, a treatment for signs and symptoms of benign prostatic hyperplasia, or an enlarged prostate.
And the FDA sent a warning letter to Sanofi-Aventis SA accusing the French drugmaker of distributing misleading promotional material on its Uroxatral
treatment for urinary problems caused by an enlarged prostate.
Nickel and his associates studied alfuzosin (Uroxatral
) because [alpha]-blockers can relax smooth muscle in the prostate and the bladder neck and may reduce neurogenic inflammation of the lower urinary tract.
Some examples include tamsulosin (Flomax) and alfuzosin (Uroxatral
) reduced the relative risk for any worsening of lower urinary tract symptoms by 26%, according to data reported by Dr.
A previous study, presented at the 2006 annual meeting of the European Association of Urology, reported that the combination of sildenafil 25 mg/day and the [[alpha].sub.1]-blocker alfuzosin (Uroxatral
) 10 mg/day was more effective than either agent was alone in men with previously untreated LUTS and ED.
For 12 weeks, 20 men took 10 mg daily of alfuzosin (Uroxatral
), an alphat-blocker that has been shown to relieve LUTS with "minimal sexual and cardiovascular side effects." Another 21 men took 25 mg of sildenafil (Viagra) each day, while the remaining 21 men took both medications.
In the second study, investigators combined sildenafil (Viagra) with alfuzosin (Uroxatral
), an alph[a.sub.1]-blocker, as a therapy for previously untreated lower urinary tract symptoms (LUTS) and erectile dysfunction.
Hellstrom and his associates enrolled 57 healthy men who received 5 days of treatment with tamsulosin (Flomax) 0.8 mg once daily, 5 days of treatment with alfuzosin (Uroxatral
) 10 mg once daily, or 5 days of placebo.
Since the panel's decision, the FDA has approved alfuzosin (UroXatral
), a selective [[alpha].sub.1]-adrenergic blocker for the treatment of benign prostatic hypertrophy.
Drugs known as alpha-blockers--alfuzosin (Uroxatral
) silodosin (Rapaflo) or tamsulosin (Flomax)--or anticholinergic drugs like tolterodine (Detrol) or oxybutynin (Ditropan) may be used to treat urinary symptoms.