Uno de los mecanismos propuestos para explicar el aumento de la VLDL
(rica en trigliceridos) con las modificaciones de la LDL-C, es que la LDL-C pierde sus esteres de colesterol y almacena trigliceridos (Fielding et al.
Cholesterol ester transfer protein (CETP) exchanges neutral lipids between lipoproteins, causing a net movement of cholesterol from HDL and LDL to CM and VLDL
and a net movement of triglyceride in the reverse direction.
Serum was separated by centrifugation and analyzed on the same day for lipid profile (total cholesterol, triglycerides, HDL cholesterol, VLDL
cholesterol, LDL cholesterol), apolipoproteins: Apo A-I ApoB 6-11).
This calculation assumes--often erroneously as TG levels rise--that TG consists only of VLDL
particles and that VLDL
composition contains five times more TG than cholesterol molecules.
Because particles of LDL, intermediate-density lipoprotein (IDL) and VLDL
each contain one apolipoprotein B (ApoB) protein, ApoB concentration may give a better indication of large lipoprotein particle concentration than measurements of cholesterol concentrations alone.
In the endogenous pathway most triglycerides in the liver are packed into VLDL
and derived from the diet after recirculation from adipose tissue.
In another study, involving 618 participants, a combination of 20 mg of simvastatin and 160 mg of fenofibrate lowered LDL by 31%, VLDL
by 48%, and triglycerides by 43% and raised HDL by 19%, compared with reductions of 26% in LDL, 24% in VLDL
, and 20% in triglycerides and an increase of 10% in HDL in those who received 20 mg of simvastatin alone (Am.
Compared with healthy controls and people with inactive SLE, the patients with active SLE had significantly higher levels of triglycerides and VLDL
cholesterol, and lower levels of HDL cholesterol.
The only way to be able to account for all the cholesterol, to match the total cholesterol value, is to use subtraction as in the Friedewald formula, which assumes that the relationship between cholesterol and TG in VLDL
is constant and that all other fractions of lipoprotein, if present, are all LDL.
Targeted Genetics' collaborators have generated initial data showing reduction of total cholesterol in a mouse model using an AAV vector to administer the gene for VLDL
We want doctors to consider triglycerides high if they're over 150, because the bulk of the people who have this bad VLDL
have triglycerides between 190 and 210, to go along with HDLs under 40.
His study indicates that fish oil speeds LDL synthesis by changing the size and chemical composition of certain VLDL
particles made by liver cells.