Splenic hamartoma, otherwise known as splenoma or splenadenoma, is another rare vasoformative
lesion of the spleen.
15,16) It is a vasoformative
malignancy that originates in endothelial cells and occurs most frequently in the skin and superficial soft tissues, although the deep tissues and the viscera have also been affected.
Formal excisional biopsies of multiple satellite neck lesions were consistent with a benign vasoformative
lesion, favouring an ulcerated pyogenic granuloma.
B henselae stimulates endothelial proliferation, producing vasoformative
lesions that can enlarge, forming large tumors in the skin, bone, bone marrow, respiratory or gastrointestinal tract, lymph nodes, or the central nervous system.
retinal cells to release a vasoformative
factor, VEGF, which has been
This rudimentary vasoformative
architecture is clearly demonstrated with reticulin staining (Figure 2).
(angiogenic) tumors of the soft tissues of the head and neck account for fewer than 0.
Since epithelioid hemangioendotheliomas and angiosarcomas may express cytokeratins, even if a vasoformative
tumor is keratin positive, the tumor should be stained with vascular markers.
They are benign vascular malformations that originate in mesodermal nests of vasoformative
The tumor typically shows features of angiosarcoma including vasoformative
architecture with hobnailed appearance (Figure 3) and it has infiltrative margins.
This case also showed a transition to a higher-grade tumor, which was vaguely vasoformative
and mitotically active, suggesting progression to an EA.
The cytologic appearance can be epithelioid, spindled, or pleomorphic (Figure 6, A through C), while the architecture can be vasoformative
, sievelike, kaposiform, or solid (Figure 7, A through D).