This unique technology has enabled several FDA-approved products, including Amgen's Kyprolis, Baxter International's Nexterone, Acrotech Biopharma's Evomela, Melinta Therapeutics' Baxdela, Sage Therapeutics' Zulresso, Merck and Co.'s Noxafil and Pfizer's Vfend
. There are many Captisol-enabled products currently in various stages of development.
The medications that can cause these skin-related adverse events are methotrexate, voriconazole (Vfend
), and BRAF inhibitors.
In the case of GM positivity in two successive serum, sputum and/or bronchoalveolar lavage samples, amphotericin-B was stopped and 4 voriconazole (Vfend
; Phizer Turkey, Ortakoy, Istanbul, Turkey) therapy was started.
The topical antibiotic was discontinued, and topical voriconazole (1 drop OS q4h-q6h; Vfend
, 200 mg/vial suspended in preservative-free saline for a final concentration of 10 mg/mL, Roerig/Pfizer, New York, NY, USA) was initiated.
Other useful agents may be voriconazole (VFend
), caspofungin (Cancidas), micafungin (Mycamine), or posaconazole (Noxafil).
In situations where the disease becomes refractory, a broader spectrum drug of a more potent nature such as voriconazole (Vfend
; Pfizer Labs, New York, NY, USA), caspofungin (Cancidas; Merck & CO., Whitehouse Station, NJ, USA), and amphotericin B (Fungizone; Bristol-Myers Squibb Co., Princeton, NJ, USA) is suggested.
M2 EQUITYBITES-October 1, 2013-Mylan Inc reports availibility of first generic VFEND
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Those with weak (30%-50%) inhibitory effects included fluticas-one, voriconazole (Vfend
), nifedipine, erythromycin, sertraline (Zoloft), haloperidol (Haldol), and trazodone, and those with negligible (less than 20%) inhibitory effects included midazolam (Versed), quetiapine (Seroquel), venlafaxine (Effexor), citalopram (Celexa), clarithromycin (Biaxin), metronidazole (Flagyl), cyclosporine, sirolimus (Rapamune), and ondansetron (Zofran), said Dr.
The novel, oral broad-spectrum anti-fungal, voriconazole (Vfend
) is a possibility, but is rarely used because it is so poorly tolerated, Dr.
These include cimetidine (Tagamet), fluconazole (Diflucan), ketoconazole (Nizoral), voriconasole (Vfend
), etravirine, felbamate (Felbatol), fluoxetine (Prozac), fluvoxamine (Luvox), and ticlopidine (Ticlid).
Decision Resources (Waltham, MA), one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, said that, because of their improvements in safety and efficacy, physicians are increasingly prescribing next-generation antifungals such as Pfizer's Vfend
, Schering-Plough's Noxafil, Merck's Cancidas, Astellas' Mycamine and Pfizer's Eraxis.