Vinca alkaloids


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Related to Vinca alkaloids: vinblastine, vincristine, paclitaxel, Taxanes

Vinca alkaloids

Cytotoxic drugs used to prevent the replication of cells.
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Similar to the vinca alkaloids and taxanes, 6.02 is now a fully synthesized therapeutic, originally derived from naturally occurring compounds.
Born on September 23, 1917, Dr Asima Chatterjee has various contributions on the research of vinca alkaloids and the development of anti-epileptic and anti-malarial drugs.
Natural sources of drugs, such as paclitaxel (Taxus brevifolia) and Vinca alkaloids, are examples for the value of traditionally used plants for modern drug development.
Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells.
APP-111 is a platform technology that may have activity in other tumor types that have previously responded to taxanes or vinca alkaloids.
These include the taxanes (paclitaxel, docetaxel) and the vinca alkaloids (vincristine, vinblastine).