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The use of genetically engineered viruses to infect and kill tumor cells.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
In addition to his role as center director and professor of the Biodesign Center for Immunotherapy, Vaccines and Virotherapy at ASU, Dr.
Oncolytic virotherapy as an immunotherapeutic strategy for multiple myeloma.
"This study has clearly confirmed that oncolytic virotherapy is able to create an inflamed phenotype and sensitize the tumor to immune checkpoint blockade," said Dr.
It's very significant because it shows, contrary to recent scientific claims, that virotherapy can be combined with cell therapy for a positive effect," said the study's corresponding author Balveen Kaur, Ph.D., professor and vice chair of research in the Vivian L.
Previous scientific wisdom discredited combining virotherapy and externally added NK cell therapy to the body's natural killer (NK) cells, but there could be clear cancer-fighting benefits - providing enough external NK cells are deployed to destroy the tumor and stop its spread, as revealed in this paper.
In the present paper, we report about our experience gained with PIPAC since July 2016 at a tertiary cancer center offering all other therapeutic options for peritoneal metastasis, including in particular palliative systemic chemotherapy, intraperitoneal chemotherapy, intraperitoneal virotherapy [28], cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy (HIPEC).
Neutralizing antibodies are highly prevalent and can reduce the efficacy of repeat injections although how antivector immunity influences the clinical or biologic response of intratumoral virotherapy is not known.
One emerging treatment modality is oncolytic virotherapy. This technique involves targeting cancer cells using oncolytic viruses (OVs), standard viruses genetically engineered to replicate selectively in cancer cells.