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 (hī′ə-lo͝o-rŏn′ĭ-dās′, -dāz′)
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌhaɪəlʊˈrɒnɪˌdeɪs; -ˌdeɪz)
(Biochemistry) an enzyme that breaks down hyaluronic acid, thus decreasing the viscosity of the medium containing the acid
[C20: hyalo- + Greek ouron urine + -id3 + -ase]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌhaɪ ə lʊˈrɒn ɪˌdeɪs, -ˌdeɪz)

an enzyme that decreases viscosity in the tissue spaces of the body by breaking down hyaluronic acid: used as an ingredient for diffusing injected drugs.
[1935–40; hyaluron(ic acid) + -id- + -ase]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hyaluronidase - an enzyme (trade name Hyazyme) that splits hyaluronic acid and so lowers its viscosity and increases the permeability of connective tissue and the absorption of fluids
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Jones added that he uses 10 U of Vitrase (hyaluronidase) for each 0.1 cc of Juvederm that he estimates should be removed.
Vitrase (hyaluronidase ovine, ISTA Pharmaceuticals Inc.) is the first and only pure, preservative-free, thimerosal-free, ovine hyaluronidase.
Highly purified bovine hyaluronidase (Vitrase) is the only vitreolytic agent that has passed phase III trials.Hyaluronidase basically acts on the glycoside bonds of hyaluronan and other mucopolysaccharides in the vitreous and causes vitreous liquefaction.
Hylenex and Vitrase, the new brand name producers of hyaluronidase that came on line in 2004, cost eight times what our local compounder charges us.
The company added that ISTAa[euro](tm)s four prescription products, Bromday, Bepreve, Istalol, and Vitrase, will complement its existing prescription ophthalmology products, including Lotemax and Besivance, and branded over the counter (OTC) eye vitamins PreserVision and Ocuvite.
Hyaluronidase products approved by the United States Food and Drug Administration (FDA) have included those derived from bovine (AMPHADASE, [R] Amphastar Pharmaceuticals, Inc, Rancho Cucamonga, CA) and ovine(Vitrase, [R] ISTAPharmaceuticals, Inc., Irvine, CA) sources, along with a recombinant human product (Hylenex, [R] Halozyme Therapeutics, San Diego, CA; rHuPH20).
Vitrase, on the other hand, is a formulation of hyaluronidase extracted from ovine (ram) testicles.
Separately, an FDA committee said last month that Vitrase, an experimental drug, offers benefits that outweigh risks for treating vitreous hemorrhage, a form of bleeding in the eye that often occurs in diabetes patients.