Waxy degeneration

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(Med.) amyloid degeneration. See under Amyloid.

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Such organs are enlarged, firm and pale in macroscopic appearance, with a waxy texture to their cut surface, a feature which led VonRokitansky in 1842 to refer this condition as "waxy degeneration" or "lardaceous disease" and subsequently named by Virchow in 1853 as AMYLOID, on the basis of color after staining with iodine and sulfuric acid, under the mistaken belief that the material was starch like (AMYLON-STARCH).