Werner syndrome


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Related to Werner syndrome: progeria, ataxia telangiectasia

Wer·ner syndrome

 (vĕr′nər) or Wer·ner's syndrome (-nərz)
n.
An autosomal recessive disorder characterized by short stature and the appearance of premature aging after puberty, with early development of conditions such as cataracts, cardiovascular disease, osteoporosis, and malignancies.

[After Carl W. Otto Werner (1879-1936), German physician.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Werner syndrome (WS) is a rare autosomal recessive disease characterized by premature aging, which was first described by Werner in 1904 [4].
Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell.
Lebel et al., "Mitochondrial dysfunction in some oxidative stress-related genetic diseases: ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome," Biogerontology, vol.
Werner syndrome is a genetic disorder that causes people to age more rapidly than normal.
It is caused by null mutations at WRN locus, which codes for a member of RecQ family of DNA helicases.6-9,11 The disease is associated with excessive synthesis of collagen type I and III which is dependent on elevated messenger RNA(mRNA) levels.6 The locus of Werner Syndrome has been found on the short arm of chromosome 8 in both Japanese and non Japanes.5,7,11 Fibroblasts isolated from WS patients exhibit genomic instability, increased sensitivity to specific DNA damaging agents, slow proliferation, lengthened S-phase, and accelerated replicative senescence.5,7,16
Furthermore, a number of inherited conditions, for example Down syndrome, Fanconi anemia, Bloom syndrome, Wiskott-Aldrich syndrome, dyskeratosis congenita, Werner syndrome, Shwachman syndrome, Blackfan-Diamond syndrome, and Klinefelter syndrome, carry an increased risk of AML [5,6].
Flies with damage to the gene share key features with people afflicted by the rapid ageing condition Werner syndrome. In particular, the flies have unstable DNA and their chromosomes are often altered.
Flies with damaged genes share key features with people hit by rapid ageing condition Werner syndrome. Oxford University's Dr Lynne Cox said it will "help us understand normal ageing" - increasingly seen by scientists as important with an ageing population.
A small handful of medical conditions are associated with premature graying, one example being Werner Syndrome, a rare disorder characterized by an accelerated rate of aging following the onset of puberty.
The NIEHS has made a similar investment in projects investigating diseases that cause premature aging, such as Werner syndrome. "All of these inherited diseases have allowed us to understand pathways ...