Vitamin C alleviates aging defects in a stem cell model for Werner syndrome
Mitochondrial dysfunction in some oxidative stress-related genetic diseases: ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome
," Biogerontology, vol.
Our findings show that the gene mutation that causes Werner syndrome
results in the disorganization of heterochromatin, and that this disruption of normal DNA packaging is a key driver of aging," says Juan Carlos Izpisua Belmonte, a senior author on the paper.
6 The locus of Werner Syndrome
has been found on the short arm of chromosome 8 in both Japanese and non Japanes.
A small handful of medical conditions are associated with premature graying, one example being Werner Syndrome
, a rare disorder characterized by an accelerated rate of aging following the onset of puberty.
The NIEHS has made a similar investment in projects investigating diseases that cause premature aging, such as Werner syndrome
When defective, they are linked to genetic diseases such as Bloom syndrome, which carries an increased risk of cancer, and Werner syndrome
Regulation of c-fos expression in senescing Werner syndrome
fibroblasts differs from that observed in senescing fibroblasts from normal donors.
These premature aging syndromes are characterized in progeria by growth retardation and accelerated degenerative changes of the cutaneous, musculoskeletal, and cardiovascular systems in young patients , and in Werner syndrome
, for which recently the a candidate gene has been identified , by an early-onset and accelerated rate of development of major geriatric disorders such as atherosclerosis, diabetes mellitus, osteoporosis, and various neoplasms .