Some neurological disorders related to long term alcoholism are predominantly due to inadequate nutrition (The thiamine deficiency that causes Wernicke's encephalopathy
), but others appear to involve the neurotoxicity of ethanol on brain (Alcohol withdrawal syndrome and dementia) and peripheral nerves (Alcoholic neuropathy and myopathy).
FDA placed a clinical hold on the fedratinib program in November 2013 after potential cases of Wernicke's encephalopathy
were reported among subjects (approximately 1%) in clinical trials.
still remains a clinical diagnosis.
: Both Thiamine and Magnesium Are Important
WKS is the concurrence of Wernicke's encephalopathy
(an acute, life-threatening condition marked by ataxia, confusion, and ocular signs) and Korsakoff's psychosis (a long-term, debilitating amnestic syndrome).
As previously reported, JAKARTA-2 was stopped prematurely due to a clinical hold placed on the fedratinib program by the US Food and Drug Administration after potential cases of Wernicke's encephalopathy
were reported in eight out of 877 patients receiving one or more doses (less than 1% of treated patients).
These processes could consume cofactors such as thiamine and disturb electrolytes, resulting in intracellular potassium shift (hypokalemia) and thiamine deficiency, which could manifest themselves as paralysis, cardiac arrhythmias, and acute Wernicke's encephalopathy
HG can be associated with significant morbidity including pneumomediastinum, renal failure, liver dysfunction, Boerhaave's syndrome, and Wernicke's encephalopathy
: New clinical settings and recent advances in diagnosis and management.
(WE) is a neuropsychological dysfunction affecting the cognitive dimension of the brain after long-term abuse of alcohol due to deficiency of thiamine (Vitamin [B.sub.1]).
Zahr and Pfefferbaum review the structural brain changes found in people with alcohol-related neurological conditions, such as Wernicke's encephalopathy
and Korsakoff syndrome, as a framework for understanding brain changes that occur in individuals with alcohol use disorder (AUD) in the absence of those conditions.
At the request of the authors, the article titled "A Fatal Case of Wernicke's Encephalopathy
after Sleeve Gastrectomy for Morbid Obesity"  has been retracted.