is a systemic, infectious disease affecting numerous organs.
is an extremely rare condition caused by a Gram-positive actinobacteria (Tropheryma whipplei), first described by George Hoyt Whipple in 1907 .
Granulomas in the stomach can be due to several diseases, such as Crohn's disease, sarcoidosis, infections, lymphoma, adenocarcinoma, Whipple's disease
, Langerhans cell histiocytosis, gastric perforation, and vasculitis .
Tropheryma whipplei and Whipple's disease
. J Infect.
- Primary mucosal abnormalities: Celiac disease, tropical sprue, Whipple's disease
, amyloidosis, Giardiasis, H.pylori infection
Sarcoidlike granulomas as an early manifestation of Whipple's disease
, caused by Tropheryma whipplei bacteria, is a rare disease, with an annual worldwide incidence of about 12 new cases.
is a rare, chronic, and infectious systemic disease caused by the bacterium Tropheryma whipplei, a member of the diverse order of Actinomycetales, usually found in soil .
(1), (3) It was generally held that - unlike the myriad other causes of mesenteric lymphadenopathy including metastatic carcinoma, sarcoma, carcinoid, AIDS-related lymphadenopathy, Whipple's disease
and TB - only mesenteric lymphoma results in bulky lymphadenopathy that produces the sandwich sign.
There exists a relationship between granulomatous diseases, especially sarcoidosis, and Whipple's disease
as a form of seronegative enteritis-associated arthritis.
But it is doubtful that they would know diseases such as West Syndrome, Whipple's disease
, Buerger's disease, yellow-nail syndrome, empty sella syndrome, or Job (as in the Old Testament) syndrome.
Arthritis associated with diarrhea, suggests inflammatory bowel disease or Whipple's disease
(excessive deposits of fat in the intestinal lymphatic tissue).