Mesonephric carcinoma of the endocervix is a rare malignancy arising from remnants of the Wolffian duct
system, in contrast to many other neoplasms of the gynecologic tract, which are Mullerian derived.
Different interpretations of the developmental mechanism of Mullerian duct has been proposed and Felix concept in 1912 as an independent outgrowth from the ostium changed to Grunwald theory that the Mullerian duct splits off from the Wolffian duct
.  Potemkina DA  recognised the development of the Mullerian duct that depends on the presence of the Wolffian duct
after noticing a simultaneous thickening of the side of the Wolffian duct
before the ostial rudiment of the Mullerian duct appeared.
Since they are congenital remnants of the Wolffian duct
, they arise from the mesosalpinx, specifically the broad ligament or fallopian tube.
In normal embryological development, the epididymis and vas deferens arise from the Wolffian duct
It is true that the exact etiology of such anomalies is still unknown, but it has been established that they have their origin in a mesonephric (Wolffian duct
) anomaly.[sup] The mesonephric anomaly with the absence of the Wolffian duct
opening into the urogenital sinus and therefore of the ureteral bud sprouting, justifies the blind vagina and unilateral renal agenesis.
Embryologically, duplication occurs when two separate ureteric buds arise from a single Wolffian duct
. Interestingly, and explaining the Weigert-Meyer rule, the future lower pole ureter separates from the Wolffian duct
earlier and migrates superiorly and laterally as the urogenital sinus grows.
A mutation in the HSD17B3 gene blocks the synthesis of testosterone in the fetal testis resulting in normal male Wolffian duct
structures but with female external genitalia at birth.
The genital kidney of the Rhyacotritonidae is characterized by a number of characteristics most similar to that of Sirenidae (i.e., the testis communicates with the Wolffian duct
via a sequential arrangement of vasa efferentia, renal corpuscles, and efferent epididymal ducts; no longitudinal duct or afferent epididymal ducts were observed), many of which have not been described previously in other salamanders.
Surface of the rooster spermatozoa changes in passing through the Wolffian duct
In general, anurans have three nephrostomial tubules, which join to form a common tubule, the Wolffian duct
. Evaginations of the dorsal aorta form paired glomeruli, which are partially surrounded by out-pocketing of the nephrostomial ducts (Bowman's capsules).
At this time, androgens stimulate the Wolffian duct
system to grow and develop into epididymis, vas deferens, and seminal vesicles.
The first two theories both suggest cellular transformations in either the Wolffian duct
system or coelomic mesothelium but can only account for lesions in close proximity to the pelvic organs.